In the southeast of Louisiana, on the banks of the Mississippi River, lies the conglomerate city-parish of New Orleans. With a population of 383,997, it is the most populated city in Louisiana, the third-most populous in the Deep South, and the twelfth-most populous in the southeastern United States, according to the 2020 U.S. Census. Being an important port, New Orleans is known as the Gulf Coast's larger economic and commercial center.

New Orleans is a world-renowned city for its exceptional music, Creole cuisine, peculiar dialects, and annual celebrations and festivals, especially Mardi Gras. The French Quarter, the city's historical district, is famous for its Spanish and French Creole architecture and vibrant nightlife on Bourbon Street. The city's multi-cultural and linguistic history is a significant factor in why it is referred to as the "most unique" in the United States. Additionally, New Orleans' significant impact on the film industry and popular culture has earned it the moniker "Hollywood South."

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