The University of Arizona is situated in Tucson, Arizona, which serves as the county seat of Pima County. Tucson is the second-largest city in Arizona, with a population of 542,629 based on the 2020 U.S. Census. Its metropolitan statistical area (MSA) has a population of 1,043,433, and it is part of the Arizona Sun Corridor, anchored by Phoenix and Tucson. The Tucson and Nogales combined statistical area is larger. Tucson is located 60 miles (97 km) north of the US-Mexico border and 108 miles (174 km) southeast of Phoenix. As of 2014, it is the 53rd-largest metropolitan area and the 34th-largest city in the United States.

The climate of Tucson, Arizona, is characterized as a hot desert climate with two distinct seasons: a hot summer and a mild winter. Tucson receives the most precipitation during the North American Monsoon in summer and Pacific storms in January, averaging 10.61 inches (269.5 mm) per year. Fall and spring are typically dry and sunny. Despite being located at the same latitude as Phoenix, Tucson is slightly cooler and wetter due to its higher elevation and orographic lift in the nearby mountains. Although Tucson can experience higher daytime temperatures in the winter, it still remains cooler than Phoenix.

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